This sentence should not ever be used unironically.
It's not like beasts of burden were magically suited to that task before they were used and selectively bred for it. Do you think wild horses and donkeys before domestication were actually better suited for those tasks than llamas and zebras?
They were beginning to approach a Bronze Age level of civilization before smallpox and the resultant social collapse wiped out the majority of the population on both continents within a few centuries. By the time Europeans got to North America, they were interacting with a post-apocalyptic civilization.
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